Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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MTH_249Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64455 AC:F64455, p()=4E-24, pid=28%; Belongs to the SIS family. PHI subfamily. (197 aa)    
Predicted Functional Partners:
fae-hps
D-arabino 3-hexulose 6-phosphate formaldehyde lyase related protein; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
 
 
 0.995
fbp
Conserved protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
 0.911
MTH_888
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:D64380 AC:D64380, p()=6.3E-25, pid=30%.
    
  0.908
MTH_1546
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64455 AC:F64455, p()=2.6E-26, pid=25%.
  
  
 
0.905
rpl13/rps9
Ribosomal protein S16 (E.coli); L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).
       0.738
endA
tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
       0.719
MTH_1730
Phosphate transporter permease PstC homolog; Function Code:12.04 - Cell Processes, Transport of anions; similar to, sp:LN:YQGH_BACSU AC:P46339, p()=5.1E-12, pid=16%.
     
 0.650
porC
Pyruvate oxidoreductase, gamma subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:F64333 AC:F64333, p()=3.7E-52, pid=42%.
      
 0.618
fno
Conserved protein; Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and likely the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions. Is specific for reduced F420 as electron donor for the reduction of NADP; neither reduced FAD nor FMN can act as electron donor. The enzyme is also specific for NADP; NAD is not utilized as substrate; Belongs to the F420-dependent NADP reductase family.
       0.617
MTH_155
Rubredoxin; Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity).
     
 0.600
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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