STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_249Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64455 AC:F64455, p()=4E-24, pid=28%; Belongs to the SIS family. PHI subfamily. (197 aa)    
Predicted Functional Partners:
fae-hps
D-arabino 3-hexulose 6-phosphate formaldehyde lyase related protein; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
 
 
 0.992
MTH_888
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:D64380 AC:D64380, p()=6.3E-25, pid=30%.
    
  0.909
MTH_1546
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64455 AC:F64455, p()=2.6E-26, pid=25%.
  
  
 
0.905
fbp
Conserved protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
  0.900
rpl13/rps9
Ribosomal protein S16 (E.coli); L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).
       0.747
endA
tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
       0.724
fno
Conserved protein; Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and likely the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions. Is specific for reduced F420 as electron donor for the reduction of NADP; neither reduced FAD nor FMN can act as electron donor. The enzyme is also specific for NADP; NAD is not utilized as substrate; Belongs to the F420-dependent NADP reductase family.
       0.621
MTH_253
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
   0.611
rpl7ae
Ribosomal protein L7a; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
     
 0.594
rps28e
Ribosomal protein S28; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:RS28_METJA AC:P54065, p()=6.4E-16, pid=43%; Belongs to the eukaryotic ribosomal protein eS28 family.
     
 0.594
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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