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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
ppaInorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (176 aa)    
Predicted Functional Partners:
MTH_959
ATP synthase, subunit K; Function Code:2.01 - Energy Metabolism, Oxidative phosphorylation; similar to, sp:LN:ATPL_METJA AC:Q57674, p()=4E-19, pid=68%; Belongs to the V-ATPase proteolipid subunit family.
  
 
 0.951
atpD
ATP synthase, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane.
   
 
  0.945
atpB
ATP synthase, subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.
   
 
 0.945
atpA
ATP synthase, subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity); Belongs to the ATPase alpha/beta chains family.
   
 
 0.942
rpl13/rps9
Ribosomal protein S16 (E.coli); L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).
  
 
 0.927
atpI
ATP synthase, subunit I; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the V-ATPase 116 kDa subunit family.
   
 
 0.919
atpE
ATP synthase, subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane.
   
 
 0.916
atpF
ATP synthase, subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane.
   
 
 0.915
MTH_481
H+-transporting ATPase; Function Code:2.01 - Energy Metabolism, Oxidative phosphorylation; similar to, gp:GI:g1652980 LN:D90910, p()=2.6E-65, pid=34%.
  
 
 0.914
MTH_482
H+-transporting ATPase; Function Code:2.01 - Energy Metabolism, Oxidative phosphorylation; similar to, gp:GI:g1652980 LN:D90910, p()=0.00005, pid=28%.
  
 
 0.914
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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