STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spt4DNA-dependent RNA polymerase, subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (60 aa)    
Predicted Functional Partners:
spt5
Transcription termination factor NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
  
 
 0.999
MTH_264
DNA-dependent RNA polymerase, subunit E; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, sp:LN:RPE1_METJA AC:Q57840, p()=3.2E-44, pid=46%.
 
 
 0.998
rps27ae
Ribosomal protein S27a; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:R27A_METJA, p()=1.4e-11, pid=%; Belongs to the eukaryotic ribosomal protein eS31 family.
 
    0.974
MTH_266
Conserved protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
 
    0.949
rps24e
Ribosomal protein S24; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:RS24_HALMA AC:P19953, p()=0.00000001, pid=21%; Belongs to the eukaryotic ribosomal protein eS24 family.
  
    0.935
MTH_262
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64464 AC:G64464, p()=0.0000046, pid=23%.
       0.840
eif2g
Translation initiation factor eIF-2, gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
  
    0.834
rps6e
Ribosomal protein S6; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:RS6E_METJA AC:P54067, p()=4.9E-25, pid=41%; Belongs to the eukaryotic ribosomal protein eS6 family.
 
    0.831
MTH_1425
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...]
 
     0.815
argH
Argininosuccinate lyase; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, sp:LN:ARLY_METJA AC:Q58201, p()=6.9E-122, pid=50%.
       0.790
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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