STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
MTH_280Coenzyme F420-reducing hydrogenase, beta subunit homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:F64408 AC:F64408, p()=4.3E-223, pid=55%. (689 aa)    
Predicted Functional Partners:
MTH_281
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp_new:GI:e316080:g2104411, p()=4.3E-10, pid=21%.
       0.780
MTH_1354
NADH oxidase; Function Code:9.04 - Metabolism of Cofactors and Vitamins, Nicotinate and nicotinamide metabolism (NADP); similar to, pir:LN:A64381 AC:A64381, p()=5E-126, pid=54%.
   
 0.752
MTH_1502
Succinate dehydrogenase, flavoprotein subunit; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:Y033_METJA AC:Q60356, p()=2.9E-139, pid=51%.
  
  
 0.696
pyrK
Cytochrome-c3 hydrogenase, gamma subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
     
 0.597
MTH_157
Flavoprotein A homolog (III); Function Code:13.07 - Other, Unclassified; similar to, pir:LN:S66533 AC:S66533, p()=4.1E-60, pid=68%.
     
 0.583
fno
Conserved protein; Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and likely the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions. Is specific for reduced F420 as electron donor for the reduction of NADP; neither reduced FAD nor FMN can act as electron donor. The enzyme is also specific for NADP; NAD is not utilized as substrate; Belongs to the F420-dependent NADP reductase family.
      
 0.570
MTH_167
S-adenosyl-L-methionine uroporphyrinogen methyltransferase; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, pir:LN:A42471 AC:A42471, p()=5.9E-84, pid=64%; Belongs to the precorrin methyltransferase family.
 
   
 0.559
pyrF
Orotidine 5' monophosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
     
 0.543
tfb
Transcription initiation factor TFIIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
     
 0.543
iorA
Indolepyruvate oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
  
  
 0.534
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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