STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_404Ribokinase; Function Code:1.03 - Carbohydrate Metabolism, Pentose phosphate cycle; similar to, sp:LN:RBSK_HAEIN AC:P44331, p()=1.1E-20, pid=27%; Belongs to the carbohydrate kinase PfkB family. (298 aa)    
Predicted Functional Partners:
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
 0.945
ehaS
Formylmethanofuran:tetrahydromethanopterin formyltransferase II; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, sp:LN:FTR_METTH AC:P21348, p()=1.6E-44, pid=36%; Belongs to the FTR family.
     
 0.934
rpiA
Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
    
 0.924
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
    
 0.924
MTH_1584
Phosphomannomutase; Function Code:1.05 - Carbohydrate Metabolism, Fructose and mannose metabolism; similar to, gp:GI:g1272329 LN:MTU51624, p()=1.3E-88, pid=38%; Belongs to the phosphohexose mutase family.
  
 
 0.922
MTH_402
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:e1226:g1364210, p()=0.8, pid=04%.
       0.856
pdxS
Ethylene-inducible protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
    
 0.837
pdxT
Conserved protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
    
 0.834
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function Code:5.10 - L-Amino Acid Metabolism, Histidine metabolism; similar to, gp:GI:g150053, p()=1.1E-66, pid=44%.
  
  
 0.755
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.732
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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