Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
MTH_433Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64495 AC:C64495, p()=5.7E-15, pid=31%; Belongs to the UPF0201 family. (132 aa)    
Predicted Functional Partners:
MTH_434
UMP/CMP kinase related protein; Function Code:4.02 - Nucleotide Metabolism, Pyrimidine metabolism; similar to, pir:LN:F64474 AC:F64474, p()=2.5E-30, pid=34%; Belongs to the UPF0200 family.
 
    0.948
MTH_435
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y209_METJA AC:Q57662, p()=1.1E-52, pid=47%.
 
   
 0.806
MTH_473
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1707057, p()=1.7E-49, pid=38%.
       0.714
MTH_689
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y213_METJA AC:Q57666, p()=0.0000017, pid=26%.
  
   
 0.649
MTH_577
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64421 AC:A64421, p()=2.4E-32, pid=31%.
  
     0.645
purP
Conserved protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family.
  
   
 0.607
MTH_583
Conserved protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
       0.569
cca
tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
       0.569
pfdB
Conserved protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
  
     0.569
MTH_890
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64502 AC:F64502, p()=4.5E-15, pid=24%.
 
     0.554
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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