STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_437Endo-1,4-beta-glucanase; Function Code:7.02 - Metabolism of Complex Carbohydrates, Polysaccharde and starch metabolism polymers (glycogen--cellulose--starch); similar to, sp:LN:Y555_METJA AC:Q57975, p()=6.8E-99, pid=55%. (343 aa)    
Predicted Functional Partners:
MTH_436
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1652318 LN:D90904, p()=0.13, pid=17%.
       0.780
MTH_414
Asparagine synthetase; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, sp:LN:ASNH_METJA AC:Q58516, p()=6.4E-73, pid=39%.
  
  
 0.607
MTH_981
Aminopeptidase P; Function Code:10.12 - Degradation of proteins, peptides, and glycopeptides; similar to, pir:LN:F64400 AC:F64400, p()=1.1E-45, pid=35%; Belongs to the peptidase M24B family.
 
  
 0.552
MTH_435
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y209_METJA AC:Q57662, p()=1.1E-52, pid=47%.
       0.544
MTH_1894
Aspartate aminotransferase homolog; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, sp:LN:AAT_METJA AC:Q60317, p()=6.1E-82, pid=46%.
  
 
 0.543
dapL
Aspartate aminotransferase related protein; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. Is also able to catalyze the reverse reaction in vitro, i.e. the transamination of LL-diaminopimelate with 2- oxoglutarate to produce 2-oxo-6-aminopimelate (in equilibrium with tetrahydrodipicolinate) and glutamate. Has maximal aminotransferase activity using 2-oxoglutarate as an amino group acceptor, and cannot use oxaloacetate instead o [...]
  
 
 0.513
mre11
Rad32 related protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
       0.510
MTH_897
Pyrroline-5-carboxylate reductase; Function Code:5.09 - L-Amino Acid Metabolism, Arginine and proline metabolism; similar to, sp:LN:PROC_ECOLI AC:P00373, p()=3.1E-16, pid=21%.
  
    0.497
MTH_1546
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64455 AC:F64455, p()=2.6E-26, pid=25%.
       0.436
MTH_434
UMP/CMP kinase related protein; Function Code:4.02 - Nucleotide Metabolism, Pyrimidine metabolism; similar to, pir:LN:F64474 AC:F64474, p()=2.5E-30, pid=34%; Belongs to the UPF0200 family.
       0.412
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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