Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
MTH_437Endo-1,4-beta-glucanase; Function Code:7.02 - Metabolism of Complex Carbohydrates, Polysaccharde and starch metabolism polymers (glycogen--cellulose--starch); similar to, sp:LN:Y555_METJA AC:Q57975, p()=6.8E-99, pid=55%. (343 aa)    
Predicted Functional Partners:
MTH_436
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1652318 LN:D90904, p()=0.13, pid=17%.
       0.779
MTH_1546
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64455 AC:F64455, p()=2.6E-26, pid=25%.
       0.714
MTH_435
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y209_METJA AC:Q57662, p()=1.1E-52, pid=47%.
       0.541
MTH_981
Aminopeptidase P; Function Code:10.12 - Degradation of proteins, peptides, and glycopeptides; similar to, pir:LN:F64400 AC:F64400, p()=1.1E-45, pid=35%; Belongs to the peptidase M24B family.
 
  
 0.538
MTH_414
Asparagine synthetase; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, sp:LN:ASNH_METJA AC:Q58516, p()=6.4E-73, pid=39%.
  
  
 0.456
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
       0.436
MTH_649
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g495021, p()=1.5E-09, pid=35%; Belongs to the snRNP Sm proteins family.
       0.428
MTH_434
UMP/CMP kinase related protein; Function Code:4.02 - Nucleotide Metabolism, Pyrimidine metabolism; similar to, pir:LN:F64474 AC:F64474, p()=2.5E-30, pid=34%; Belongs to the UPF0200 family.
       0.402
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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