STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (579 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 0.999
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.998
MTH_472
DNA helicase II; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, gp:GI:e264229:g1524213, p()=3.8E-56, pid=22%.
 
  
 0.908
MTH_511
DNA helicase II; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, sp:LN:PCRA_STAAU AC:Q53727, p()=2.5E-60, pid=33%.
 
  
 0.814
MTH_491
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YPRB_BACSU AC:P50837, p()=7.9E-19, pid=20%.
 
     0.793
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
   
 0.767
MTH_551
DNA helicase II related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, gp:GI:e257598:g1483594, p()=8.1E-21, pid=13%.
  
  
 0.762
mdh
Lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
 
     0.761
MTH_802
Aspartokinase II alpha subunit; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, gp:GI:e255104:g1770047 LN:BSZ75208, p()=1.4E-36, pid=29%; Belongs to the aspartokinase family.
       0.750
MTH_1422
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64403 AC:G64403, p()=4.3E-49, pid=29%.
     
 0.745
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.