Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTH_477Sulfate transport system ATP-binding; Function Code:12.04 - Cell Processes, Transport of anions; similar to, gp:GI:g1381803 LN:ATU60011, p()=9.9E-43, pid=34%. (348 aa)    
Predicted Functional Partners:
MTH_478
Sulfate transport system permease protein; Function Code:12.04 - Cell Processes, Transport of anions; similar to, gp:GI:g1800187 LN:HPAC000108, p()=1.7E-15, pid=24%.
 
  
  0.984
MTH_479
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YQGG_BACSU AC:P46338, p()=0.0039, pid=13%.
    
  0.973
MTH_921
Anion transport system permease protein; Function Code:12.04 - Cell Processes, Transport of anions; similar to, sp:LN:MBPY_MARPO AC:P26246, p()=3.7E-20, pid=20%.
 
 0.896
MTH_695
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YF07_METJA AC:Q58902, p()=6.9E-18, pid=19%.
    0.667
rpl2
Ribosomal protein L8 (E.coli); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
 
     0.584
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
 
     0.526
MTH_1011
ATP-dependent 26S protease regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
  
     0.505
rps5
Ribosomal protein S2 (E.coli); With S4 and S12 plays an important role in translational accuracy.
  
     0.478
pan
ATP-dependent 26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone pro [...]
 
     0.457
tuf
Translation elongation factor, EF-1 alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
  
   
 0.424
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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