STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_486Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:D29585 AC:D29585, p()=0.9993, pid=06%. (176 aa)    
Predicted Functional Partners:
MTH_485
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:S51725 AC:S51725, p()=0.012, pid=24%.
      0.929
MTH_487
DNA helicase related protein; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, sp:LN:Y140_MYCGE AC:P47386, p()=1.1E-47, pid=17%.
      0.929
MTH_488
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:A24829 AC:A24829, p()=0.24, pid=07%.
      0.919
MTH_489
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1276470 LN:GCU24068, p()=0.54, pid=11%.
       0.562
MTH_490
Unknown; Function Code:14.00 - Unknown; similar to, gp_new:GI:g2072778 LN:MMU47023, p()=0.54, pid=08%.
       0.562
mre11
Rad32 related protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
 
 0.544
MTH_491
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YPRB_BACSU AC:P50837, p()=7.9E-19, pid=20%.
       0.531
MTH_492
ATP-dependent RNA helicase, eIF-4A family; Function Code:10.07 - Metabolism of Macromolecules, Aminoacyl tRNA synthetases and tRNA modification; similar to, sp:LN:YPRA_BACSU AC:P50830, p()=1.3E-111, pid=31%.
       0.464
rpoD
DNA-dependent RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.443
fen
DNA repair protein Rad2; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathwa [...]
    
 
 0.412
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.