Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTH_494Thermonuclease precursor; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, gp:GI:g1750126 LN:BSU66480, p()=3.6E-13, pid=30%. (173 aa)    
Predicted Functional Partners:
rtcB
Conserved protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family.
     
 0.760
mre11
Rad32 related protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
   
   0.755
aroK
Conserved protein (homoserine kinase related); Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64479 AC:G64479, p()=1.8E-36, pid=31%.
       0.671
rps4
Ribosomal protein S9 (E.coli); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 
 0.664
MTH_495
Modification methyltransferase, cytosine-specific; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:MTD1_DESDN AC:P05302, p()=8.6E-37, pid=30%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
  
  
 0.650
flpA
Fibrillarin-like pre-rRNA processing protein; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
   
 0.625
MTH_203
ATP-dependent RNA helicase, eIF-4A family; Function Code:10.07 - Metabolism of Macromolecules, Aminoacyl tRNA synthetases and tRNA modification; similar to, gp:GI:g1881268 LN:AB001488, p()=1.2E-83, pid=40%; Belongs to the DEAD box helicase family.
   
 0.625
rps5
Ribosomal protein S2 (E.coli); With S4 and S12 plays an important role in translational accuracy.
  
 
 0.586
rps3
Ribosomal protein S3 (E.coli); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.
 
 
 0.583
MTH_493
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g415630 LN:DMU03277, p()=0.992, pid=09%.
  
  
 0.576
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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