STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
MTH_495Modification methyltransferase, cytosine-specific; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:MTD1_DESDN AC:P05302, p()=8.6E-37, pid=30%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (413 aa)    
Predicted Functional Partners:
MTH_1636
S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family.
    
 0.919
mat
Conserved protein; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
     
  0.900
MTH_498
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:Y041_METJA AC:Q60346, p()=0.83, pid=06%.
 
     0.819
MTH_497
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1326398, p()=0.54, pid=02%.
 
     0.816
rpl13/rps9
Ribosomal protein S16 (E.coli); L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).
       0.713
MTH_1903
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:e284341:g1771850, p()=0.00029, pid=17%.
  
  
 0.679
MTH_494
Thermonuclease precursor; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, gp:GI:g1750126 LN:BSU66480, p()=3.6E-13, pid=30%.
  
  
 0.653
MTH_496
Endonuclease III homolog; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:GTMR_METTF AC:P29588, p()=2.2E-31, pid=30%.
     
 0.652
tgtA
tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
     
 0.626
MTH_1252
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64398 AC:F64398, p()=0.00000014, pid=16%.
   
    0.605
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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