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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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MTH_495Modification methyltransferase, cytosine-specific; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:MTD1_DESDN AC:P05302, p()=8.6E-37, pid=30%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (413 aa)    
Predicted Functional Partners:
dadD
N-ethylammeline chlorohydrolase homolog; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, where [...]
  
 
 0.912
mat
Conserved protein; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
     
  0.900
MTH_498
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:Y041_METJA AC:Q60346, p()=0.83, pid=06%.
 
     0.817
MTH_497
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1326398, p()=0.54, pid=02%.
 
     0.813
nucS
Conserved protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
     
 0.759
rpl13/rps9
Ribosomal protein S16 (E.coli); L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).
     
 0.743
MTH_494
Thermonuclease precursor; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, gp:GI:g1750126 LN:BSU66480, p()=3.6E-13, pid=30%.
  
  
 0.650
MTH_496
Endonuclease III homolog; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:GTMR_METTF AC:P29588, p()=2.2E-31, pid=30%.
       0.628
tgtA
tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
     
 0.572
MTH_1113
Conserved protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family.
       0.569
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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