STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_496Endonuclease III homolog; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:GTMR_METTF AC:P29588, p()=2.2E-31, pid=30%. (175 aa)    
Predicted Functional Partners:
MTH_212
Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA.
   
 0.967
sfsA
Sugar fermentation stimulation protein; Function Code:12.12 - Cell Processes, Broad regulatory functions; similar to, sp:LN:SFSA_ECOLI AC:P18273, p()=2.3E-20, pid=25%; Belongs to the SfsA family.
    0.954
pcn
Proliferating-cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity). In conjunction with replication factor C (RFC) stimulates DNA synthesis by PolB, relieving inhibition by replication protein A (RPA). Belongs to the PCNA family.
   
 
 0.845
MTH_497
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1326398, p()=0.54, pid=02%.
       0.794
MTH_498
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:Y041_METJA AC:Q60346, p()=0.83, pid=06%.
       0.794
MTH_499
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:Y7K7_BPP22 AC:P26750, p()=0.43, pid=02%.
       0.661
MTH_495
Modification methyltransferase, cytosine-specific; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:MTD1_DESDN AC:P05302, p()=8.6E-37, pid=30%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
 0.652
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
  
0.640
MTH_1315
Mutator MutT protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:D64443 AC:D64443, p()=7.5E-29, pid=41%.
  
  
 0.626
eif5a
Translation initiation factor, eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
 
   
 0.582
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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