STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_543Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:A56858 AC:A56858, p()=0.95, pid=11%. (354 aa)    
Predicted Functional Partners:
mre11
Rad32 related protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
   
 
 0.985
MTH_542
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YF65_METJA AC:Q58960, p()=0.00048, pid=17%.
   
 
 0.948
rad50
Intracellular protein transport protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
     
 0.821
MTH_307
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YF65_METJA AC:Q58960, p()=2.2E-77, pid=34%.
   
 
 0.781
MTH_544
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1402531 LN:D78257, p()=8.1E-16, pid=31%; Belongs to the UPF0145 family.
       0.532
MTH_545
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1272330 LN:MTU51624, p()=0.000017, pid=10%.
  
    0.467
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.