node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MTH_1384 | MTH_212 | MTH_1384 | MTH_212 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | 0.691 |
MTH_1384 | MTH_550 | MTH_1384 | MTH_550 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | DNA-dependent DNA polymerase family X; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, gp:GI:e255092:g1770035 LN:BSZ75208, p()=9.1E-56, pid=43%. | 0.676 |
MTH_1384 | fen | MTH_1384 | MTH_1633 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | DNA repair protein Rad2; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathwa [...] | 0.791 |
MTH_1384 | lig | MTH_1384 | MTH_1580 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.761 |
MTH_1384 | pcn | MTH_1384 | MTH_1312 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | Proliferating-cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity). In conjunction with replication factor C (RFC) stimulates DNA synthesis by PolB, relieving inhibition by replication protein A (RPA). Belongs to the PCNA family. | 0.956 |
MTH_1384 | polB | MTH_1384 | MTH_1405 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | DNA polymerase delta small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity); Belongs to the DNA polymerase delta/II small subunit family. | 0.748 |
MTH_1384 | polB1 | MTH_1384 | MTH_1208 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | DNA-dependent DNA polymerase family B (PolB1); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' exonuclease activity; Belongs to the DNA polymerase type-B family. | 0.858 |
MTH_1384 | polB2 | MTH_1384 | MTH_208 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | DNA-dependent DNA polymerase family B (PolB2); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' exonuclease activity. | 0.858 |
MTH_1384 | rpa | MTH_1384 | MTH_1385 | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | Replication factor A related protein; Inhibits DNA polymerase activity of PolB, which can be overcome by RFC and PNCA. Stimulates 3'-to 5'-exonuclease activity of PolB at 30 degrees Celsius, but has no effect at 50 or 70 degrees Celsius. Bind ssDNA and replication forks; replication forks structures bind both Hel308 and this protein. Has no effect on helicase activity of Hel308; may help target the helicase to DNA substrates that require DNA re-modeling. | 0.997 |
MTH_212 | MTH_1384 | MTH_212 | MTH_1384 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | 0.691 |
MTH_212 | MTH_550 | MTH_212 | MTH_550 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | DNA-dependent DNA polymerase family X; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, gp:GI:e255092:g1770035 LN:BSZ75208, p()=9.1E-56, pid=43%. | 0.973 |
MTH_212 | fen | MTH_212 | MTH_1633 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | DNA repair protein Rad2; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathwa [...] | 0.997 |
MTH_212 | lig | MTH_212 | MTH_1580 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.985 |
MTH_212 | pcn | MTH_212 | MTH_1312 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | Proliferating-cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity). In conjunction with replication factor C (RFC) stimulates DNA synthesis by PolB, relieving inhibition by replication protein A (RPA). Belongs to the PCNA family. | 0.969 |
MTH_212 | polB | MTH_212 | MTH_1405 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | DNA polymerase delta small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity); Belongs to the DNA polymerase delta/II small subunit family. | 0.968 |
MTH_212 | polB1 | MTH_212 | MTH_1208 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | DNA-dependent DNA polymerase family B (PolB1); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' exonuclease activity; Belongs to the DNA polymerase type-B family. | 0.821 |
MTH_212 | polB2 | MTH_212 | MTH_208 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | DNA-dependent DNA polymerase family B (PolB2); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' exonuclease activity. | 0.821 |
MTH_212 | rpa | MTH_212 | MTH_1385 | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | Replication factor A related protein; Inhibits DNA polymerase activity of PolB, which can be overcome by RFC and PNCA. Stimulates 3'-to 5'-exonuclease activity of PolB at 30 degrees Celsius, but has no effect at 50 or 70 degrees Celsius. Bind ssDNA and replication forks; replication forks structures bind both Hel308 and this protein. Has no effect on helicase activity of Hel308; may help target the helicase to DNA substrates that require DNA re-modeling. | 0.691 |
MTH_550 | MTH_1384 | MTH_550 | MTH_1384 | DNA-dependent DNA polymerase family X; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, gp:GI:e255092:g1770035 LN:BSZ75208, p()=9.1E-56, pid=43%. | Replication factor A related protein; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, pir:LN:F64444 AC:F64444, p()=0.0000042, pid=21%. | 0.676 |
MTH_550 | MTH_212 | MTH_550 | MTH_212 | DNA-dependent DNA polymerase family X; Function Code:10.09 - Metabolism of Macromolecules, DNA replication--modification--repair--and recombination; similar to, gp:GI:e255092:g1770035 LN:BSZ75208, p()=9.1E-56, pid=43%. | Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA. | 0.973 |