Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
Experiments
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[Homology]
Score
MTH_568Unknown; Function Code:14.00 - Unknown. (64 aa)    
Predicted Functional Partners:
htpX
Heat shock protein X; Function Code:12.06 - Cell Processes, Chaperones; similar to, pir:LN:H64509 AC:H64509, p()=1.1E-36, pid=38%; Belongs to the peptidase M48B family.
      0.932
MTH_1235
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64482 AC:A64482, p()=6.1E-50, pid=51%.
  
    0.789
MTH_577
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64421 AC:A64421, p()=2.4E-32, pid=31%.
  
    0.758
mdh
Lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.756
MTH_1648
Dihydrolipoamide dehydrogenase; Function Code:1.01 - Carbohydrate Metabolism, Glycolysis--Gluconeogenesis; similar to, pir:LN:D64379 AC:D64379, p()=8.1E-48, pid=31%.
  
 
 0.721
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
  
 0.704
MTH_1382
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64428 AC:F64428, p()=3.7E-20, pid=24%.
  
  
 0.691
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
 0.652
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.647
thsA
Chaperonin; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family.
  
 0.639
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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