STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_577Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64421 AC:A64421, p()=2.4E-32, pid=31%. (292 aa)    
Predicted Functional Partners:
MTH_435
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y209_METJA AC:Q57662, p()=1.1E-52, pid=47%.
 
  
 0.985
MTH_568
Unknown; Function Code:14.00 - Unknown.
  
    0.724
htpX
Heat shock protein X; Function Code:12.06 - Cell Processes, Chaperones; similar to, pir:LN:H64509 AC:H64509, p()=1.1E-36, pid=38%; Belongs to the peptidase M48B family.
  
    0.724
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.723
metE
Cobalamin-independent methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate (By similarity).
  
    0.706
MTH_1817
Heat shock protein X related protein; Function Code:12.06 - Cell Processes, Chaperones; similar to, pir:LN:H64509 AC:H64509, p()=0.000097, pid=09%.
  
    0.666
MTH_433
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64495 AC:C64495, p()=5.7E-15, pid=31%; Belongs to the UPF0201 family.
  
     0.645
MTH_1216
Function Code:9.05 - Metabolism of Cofactors and Vitamins, Pantothenate and CoA biosynthesis; similar to, pir:LN:A64414 AC:A64414, p()=6.1E-66, pid=38%.
 
   
 0.638
ribK
Conserved protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
  
   
 0.635
tfe
Conserved protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to tr [...]
  
    0.613
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.