STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MTH_577Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64421 AC:A64421, p()=2.4E-32, pid=31%. (292 aa)    
Predicted Functional Partners:
MTH_435
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y209_METJA AC:Q57662, p()=1.1E-52, pid=47%.
 
  
 0.994
MTH_1216
Function Code:9.05 - Metabolism of Cofactors and Vitamins, Pantothenate and CoA biosynthesis; similar to, pir:LN:A64414 AC:A64414, p()=6.1E-66, pid=38%.
 
   
 0.791
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.767
MTH_568
Unknown; Function Code:14.00 - Unknown.
  
    0.758
htpX
Heat shock protein X; Function Code:12.06 - Cell Processes, Chaperones; similar to, pir:LN:H64509 AC:H64509, p()=1.1E-36, pid=38%; Belongs to the peptidase M48B family.
  
    0.758
metE
Cobalamin-independent methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate (By similarity).
  
    0.743
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
       0.714
taw2
Met-10+ related protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
 
     0.682
MTH_1817
Heat shock protein X related protein; Function Code:12.06 - Cell Processes, Chaperones; similar to, pir:LN:H64509 AC:H64509, p()=0.000097, pid=09%.
  
    0.676
tmk
Thymidylate kinase; Function Code:4.04 - Nucleotide Metabolism, Salvage and interconversion; similar to, sp:LN:KTHY_METJA AC:Q57741, p()=5.2E-21, pid=32%.
       0.675
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.