STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nifH2Nitrogenase NifH subunit; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (265 aa)    
Predicted Functional Partners:
nifE
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE; This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor); Belongs to the NifD/NifK/NifE/NifN family.
 
 0.990
cfbD
Nitrogenase alpha chain (NifD) related protein; Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c- acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430; Belongs to the NifD/NifK/NifE/N [...]
 
 0.987
MTH_1482
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE homolog; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:g1263078 LN:AVU51863, p()=2.7E-33, pid=43%.
 
 0.980
nifD
Nitrogenase NifD subunit; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
 
 0.962
MTH_1566
Nitrogenase molybdenum-iron protein, NifN subunit; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:e303924:g1854559, p()=7.1E-159, pid=66%; Belongs to the NifD/NifK/NifE/NifN family.
 
 
 0.943
MTH_873
UDP-N-acetylmuramyl tripeptide synthetase related protein; Function Code:11.04 - Cell envelope, Murein sacculus and peptidoglycan; similar to, sp:LN:Y258_METJA AC:Q57706, p()=5.2E-25, pid=22%.
    
 0.925
nifK
Nitrogenase molybdenum-iron protein, NifK subunit; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family.
 
 
 0.917
MTH_645
Collagenase; Function Code:10.12 - Metabolism of Macromolecules, Degradation of proteins--peptides--and glycopeptides; similar to, sp:LN:Y090_METJA AC:Q57555, p()=1.3E-88, pid=46%.
     
 0.855
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
       0.841
MTH_1098
Bacteriochlorophyll synthase related protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
 
  
 0.818
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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