STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nifH2Nitrogenase NifH subunit; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (265 aa)    
Predicted Functional Partners:
nifE
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE; This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor); Belongs to the NifD/NifK/NifE/NifN family.
 
 0.999
cfbD
Nitrogenase alpha chain (NifD) related protein; Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c- acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430; Belongs to the NifD/NifK/NifE/N [...]
 
 0.984
MTH_1482
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE homolog; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:g1263078 LN:AVU51863, p()=2.7E-33, pid=43%.
 
 0.980
nifD
Nitrogenase NifD subunit; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
 
 0.970
MTH_1566
Nitrogenase molybdenum-iron protein, NifN subunit; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:e303924:g1854559, p()=7.1E-159, pid=66%; Belongs to the NifD/NifK/NifE/NifN family.
 
 
 0.942
nifK
Nitrogenase molybdenum-iron protein, NifK subunit; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family.
 
 
 0.936
MTH_873
UDP-N-acetylmuramyl tripeptide synthetase related protein; Function Code:11.04 - Cell envelope, Murein sacculus and peptidoglycan; similar to, sp:LN:Y258_METJA AC:Q57706, p()=5.2E-25, pid=22%.
    
 0.928
mrtA
Methyl coenzyme M reductase II, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
      
 0.884
MTH_645
Collagenase; Function Code:10.12 - Metabolism of Macromolecules, Degradation of proteins--peptides--and glycopeptides; similar to, sp:LN:Y090_METJA AC:Q57555, p()=1.3E-88, pid=46%.
       0.858
fno
Conserved protein; Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and likely the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions. Is specific for reduced F420 as electron donor for the reduction of NADP; neither reduced FAD nor FMN can act as electron donor. The enzyme is also specific for NADP; NAD is not utilized as substrate; Belongs to the F420-dependent NADP reductase family.
      
 0.831
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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