STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_652Ribonucleotide reductase, large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (703 aa)    
Predicted Functional Partners:
MTH_1577
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:YRUB_CLOPA AC:P23171, p()=0.000041, pid=21%.
  
 0.998
MTH_1100
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:KTHY_METJA AC:Q57741, p()=0.0000032, pid=19%.
  
 
 0.942
tmk
Thymidylate kinase; Function Code:4.04 - Nucleotide Metabolism, Salvage and interconversion; similar to, sp:LN:KTHY_METJA AC:Q57741, p()=5.2E-21, pid=32%.
  
 
 0.942
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.931
MTH_1663
Adenylate kinase homolog; Function Code:4.01 - Nucleotide metabolism, Purine metabolism; similar to, sp:LN:KAD_METJA AC:P43409, p()=5.0e-20, pid=30%; Belongs to the archaeal adenylate kinase family.
  
  
  0.914
adkA
Adenylate kinase; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:KAD_METJA AC:P43409, p()=4.5E-47, pid=48%; Belongs to the archaeal adenylate kinase family.
  
  
  0.912
MTH_1068
Conserved protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
  
  
  0.911
MTH_1619
Conserved protein (adenylate kinase related); Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates; Belongs to the adenylate kinase family. AK6 subfamily.
   
 
  0.910
cmk
Cytidylate kinase; Function Code:4.04 - Nucleotide Metabolism, Salvage and interconversion; similar to, pir:LN:H64381 AC:H64381, p()=5.2E-21, pid=32%.
    
  0.904
thyA
Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
  
  
 0.893
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.