STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_658Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:YSMA_BACSU AC:P11469, p()=0.13, pid=19%. (108 aa)    
Predicted Functional Partners:
MTH_659
Epoxidase; Function Code:13.07 - Other, Unclassified; similar to, pir:LN:S60215 AC:S60215, p()=6.1E-11, pid=28%.
  
  
 0.847
MTH_657
long-chain-fatty-acid-CoA ligase; Function Code:3.01 - Lipid Metabolism, Fatty acid biosynthesis; similar to, gp:GI:e276127:g1627854, p()=3.2E-101, pid=37%.
 
  
 0.795
MTH_984
1,3-propanediol dehydrogenase; Function Code:13.07 - Other, Unclassified; similar to, sp:LN:YIAY_ECOLI AC:P37686, p()=4.5E-70, pid=42%.
     
 0.597
ilvD
Dihydroxy-acid dehydratase; Function Code:5.06 - L-Amino Acid Metabolism, Valine--leucine and isoleucine biosynthesis; similar to, pir:LN:C64459 AC:C64459, p()=2.6E-184, pid=56%; Belongs to the IlvD/Edd family.
  
  
 0.567
queC
Conserved protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
   
 
 0.561
MTH_671
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:D64374 AC:D64374, p()=0.089, pid=10%.
 
  
 0.529
MTH_1022
Biopolymer transport protein; Function Code:12.01 - Cell Processes, Transport of amino acids--peptides and amines; similar to, gp:GI:g1001752, p()=4.6E-13, pid=19%.
 
  
 0.527
MTH_656
ATP-dependent RNA helicase related protein; Function Code:10.02 - Metabolism of macromolecules, Transcription, mRNA synthesis and modification (includes regulators; similar to, pir:LN:H64474 AC:H64474, p()=1.3E-125, pid=34%.
       0.519
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.508
nnr
Conserved protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). In the N-terminal section; belongs to the NnrE/AIBP family.
 
     0.506
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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