Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rrp42Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site; Belongs to the RNase PH family. Rrp42 subfamily. (271 aa)    
Predicted Functional Partners:
csl4
Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
  
 0.999
rrp41
Ribonuclease PH; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails; Belongs to the RNase PH family. Rrp41 subfamily.
 
0.999
rrp4
Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
 
 0.999
dnaG
Conserved protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
 
 0.987
rpl13/rps9
Ribosomal protein S16 (E.coli); L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).
  
 
 0.978
rpl37ae
Ribosomal protein L37a; Binds to the 23S rRNA.
   
 
 0.976
MTH_685
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:H64373 AC:H64373, p()=3.2E-60, pid=50%; Belongs to the SDO1/SBDS family.
  
  
 0.965
MTH_1006
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64355 AC:C64355, p()=2.5E-37, pid=42%.
  
 0.962
psmA
Proteasome, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
  
 0.957
rps6e
Ribosomal protein S6; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:RS6E_METJA AC:P54067, p()=4.9E-25, pid=41%; Belongs to the eukaryotic ribosomal protein eS6 family.
  
  0.954
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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