STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmAProteasome, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (248 aa)    
Predicted Functional Partners:
psmB
Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.999
pan
ATP-dependent 26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone pro [...]
 
 0.997
MTH_971
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1469185 LN:D50921, p()=0.85, pid=15%.
   
 0.973
MTH_685
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:H64373 AC:H64373, p()=3.2E-60, pid=50%; Belongs to the SDO1/SBDS family.
 
  
 0.956
rpl40e
Ribosomal protein L40; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:RL40_METJA AC:P54058, p()=5.1E-14, pid=55%; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.938
MTH_1639
Cell division control protein Cdc48; Function Code:12.07 - Cell Processes, Cell division; similar to, pir:LN:C64444 AC:C64444, p()=7.7E-233, pid=83%.
 
 0.919
rpl15e
Ribosomal protein L15; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:R15E_METJA AC:P54060, p()=8.6E-60, pid=66%; Belongs to the eukaryotic ribosomal protein eL15 family.
  
 0.882
rrp4
Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
 
  
 0.848
rrp42
Conserved protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site; Belongs to the RNase PH family. Rrp42 subfamily.
 
  
 0.796
MTH_1302
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y106_METJA AC:Q57570, p()=1.3E-31, pid=30%.
 
 
 
 0.783
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.