Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTH_708Thioredoxin reductase; Function Code:4.02 - Nucleotide Metabolism, Pyrimidine metabolism; similar to, gp_new:GI:e313024:g1945648 LN:BSZ94043, p()=3.8E-57, pid=42%. (303 aa)    
Predicted Functional Partners:
MTH_807
Thioredoxin; Acts to maintain redox homeostasis; functions as a protein disulfide reductase; Belongs to the glutaredoxin family.
 
 
 0.968
MTH_159
Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.934
csd
nifS protein; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:g1001708, p()=1.6E-67, pid=29%; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
  
 
 0.921
MTH_1648
Dihydrolipoamide dehydrogenase; Function Code:1.01 - Carbohydrate Metabolism, Glycolysis--Gluconeogenesis; similar to, pir:LN:D64379 AC:D64379, p()=8.1E-48, pid=31%.
 
 
 0.861
MTH_1745
Protein disulphide isomerase; Function Code:10.08 - Metabolism of Macromolecules, Protein translation and modification; similar to, gp:GI:g699219 LN:MLU15182, p()=0.000000021, pid=22%.
  
 
 0.842
MTH_476
Pyruvate dehydrogenase / acetolactate synthase; Function Code:1.08 - Carbohydrate Metabolism, Pyruvate and acetyl-CoA metabolism; similar to, gp:GI:g1881244 LN:AB001488, p()=1.8E-84, pid=32%; Belongs to the TPP enzyme family.
  
  
 0.831
MTH_1571
Molybdopterin biosynthesis protein MoeB homolog; Function Code:9.11 - Metabolism of Cofactors and Vitamins, Molybdopterin; similar to, gp:GI:e290745:g1781245, p()=1.6E-22, pid=28%.
  
  
 0.786
MTH_1095
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1653851 LN:D90917, p()=0.000000003, pid=35%.
  
 
 0.764
MTH_895
Conserved protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.
  
 
 0.764
msrB
Transcriptional regulator; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, gp:GI:e266415:g1550715, p()=5.8E-38, pid=49%; Belongs to the MsrB Met sulfoxide reductase family.
  
  
 0.690
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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