STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_708Thioredoxin reductase; Function Code:4.02 - Nucleotide Metabolism, Pyrimidine metabolism; similar to, gp_new:GI:e313024:g1945648 LN:BSZ94043, p()=3.8E-57, pid=42%. (303 aa)    
Predicted Functional Partners:
MTH_159
Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.978
csd
nifS protein; Function Code:2.06 - Energy Metabolism, Nitrogen metabolism; similar to, gp:GI:g1001708, p()=1.6E-67, pid=29%; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
  
 
 0.931
MTH_807
Thioredoxin; Acts to maintain redox homeostasis; functions as a protein disulfide reductase; Belongs to the glutaredoxin family.
 
 
 0.928
MTH_548
Sensory transduction regulatory protein; Function Code:12.12 - Cell Processes, Broad regulatory functions; similar to, gp:GI:g1652473 LN:D90905, p()=1.2E-23, pid=18%.
     
 0.861
MTH_476
Pyruvate dehydrogenase / acetolactate synthase; Function Code:1.08 - Carbohydrate Metabolism, Pyruvate and acetyl-CoA metabolism; similar to, gp:GI:g1881244 LN:AB001488, p()=1.8E-84, pid=32%; Belongs to the TPP enzyme family.
     
 0.837
MTH_1745
Protein disulphide isomerase; Function Code:10.08 - Metabolism of Macromolecules, Protein translation and modification; similar to, gp:GI:g699219 LN:MLU15182, p()=0.000000021, pid=22%.
  
 
 0.822
MTH_1648
Dihydrolipoamide dehydrogenase; Function Code:1.01 - Carbohydrate Metabolism, Glycolysis--Gluconeogenesis; similar to, pir:LN:D64379 AC:D64379, p()=8.1E-48, pid=31%.
 
 
 0.812
MTH_1095
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1653851 LN:D90917, p()=0.000000003, pid=35%.
  
 
 0.811
MTH_895
Conserved protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.
  
 
 0.811
glnA
Glutamine synthetase; Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
 
 
 0.793
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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