STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_720Unknown; Involved in DNA damage repair. (388 aa)    
Predicted Functional Partners:
MTH_721
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:D64467 AC:D64467, p()=3.9E-31, pid=22%; Belongs to the DegT/DnrJ/EryC1 family.
       0.804
nac
Conserved protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.608
ribK
Conserved protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
  
     0.597
cdc6-2
Cdc6 related protein; Involved in regulation of DNA replication. Dissociates the MCM complex and inhibits the MCM helicase activity, suggesting that it may function as a helicase loader. Binds to both specific and random double-stranded or single-stranded DNA. Belongs to the CDC6/cdc18 family.
  
     0.562
MTH_719
Function Code:11.03 - Cell envelope, Surface proteins--glycoproteins--and structures; similar to, sp:LN:CSG_METFE AC:P27373, p()=1.5E-26, pid=44%.
       0.519
MTH_1407
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64477 AC:B64477, p()=1.5E-14, pid=35%; Belongs to the UPF0147 family.
  
     0.478
cdc6-1
Cdc6 related protein; Involved in regulation of DNA replication. May play an essential role in origin recognition. Binds to DNA, with a preference for origin-specific double-stranded sequences. Does not bind single- stranded DNA. Inhibits MCM helicase activity but does not affect its oligomeric state. Belongs to the CDC6/cdc18 family.
  
     0.471
MTH_1654
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1196508, p()=0.991, pid=08%.
  
     0.448
pfdB
Conserved protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
  
     0.447
dnaG
Conserved protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
     0.447
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.