STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_722Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y187_METJA AC:Q57646, p()=0.000000027, pid=21%. (156 aa)    
Predicted Functional Partners:
MTH_1425
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...]
    
 
 0.999
cimA
2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
       0.924
trmG10
Methyltransferase related protein; Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity); Belongs to the methyltransferase superfamily. Trm-G10 family.
       0.813
MTH_725
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64489 AC:G64489, p()=1.7E-28, pid=31%.
       0.813
MTH_726
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:e306545:g1877333, p()=0.033, pid=12%.
       0.653
MTH_1282
Inosine-5'-monophosphate dehydrogenase related protein VI; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:Y188_METJA AC:Q57647, p()=1.7E-61, pid=41%.
       0.436
rps17e
Ribosomal protein S17; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:R17E_METJA AC:P54026, p()=3.3E-12, pid=46%; Belongs to the eukaryotic ribosomal protein eS17 family.
       0.436
hel308
DNA helicase related protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. Helicase with 3'-to 5'- polarity; able to unwind over 100 bp of DNA at 50 degrees Celsius. Unwinds forked DNA, preferentially on lagging strand forks; has weaker activity on Holliday junctions. Displaces the invading strand in DNA D- loops. Unwinds short oligonucleotides from dsDNA with 3'- but not blunt ends or 5'-ssDNA tails in an ATP-dependent manner. ATPase activity is stimulated by ssDNA but not dsDNA, protein binds ssDNA, dsDNA with 5'- or 3'-over [...]
       0.436
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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