STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trmG10Methyltransferase related protein; Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity); Belongs to the methyltransferase superfamily. Trm-G10 family. (336 aa)    
Predicted Functional Partners:
MTH_725
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64489 AC:G64489, p()=1.7E-28, pid=31%.
  
    0.924
cimA
2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
    0.829
MTH_722
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y187_METJA AC:Q57646, p()=0.000000027, pid=21%.
       0.813
MTH_726
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:e306545:g1877333, p()=0.033, pid=12%.
       0.812
rtcA
Conserved protein; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
  
  
 0.765
tgtA
tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
  
 0.678
MTH_858
GTP-binding protein, GTP1/OBG family; Function Code:13.07 - Other, Unclassified; similar to, pir:LN:G64475 AC:G64475, p()=9.7E-68, pid=40%.
  
  
 0.678
MTH_1414
protein-L-isoaspartate methyltransferase homolog; Function Code:10.08 - Metabolism of Macromolecules, Protein translation and modification; similar to, sp:LN:Y134_METJA AC:Q57598, p()=1.3E-43, pid=43%.
   
  
 0.677
trm1
N2,N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
 
 0.674
MTH_1768
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:H64505 AC:H64505, p()=1.4E-41, pid=30%.
   
    0.593
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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