Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MTH_726Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:e306545:g1877333, p()=0.033, pid=12%. (204 aa)    
Predicted Functional Partners:
trmG10
Methyltransferase related protein; Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity); Belongs to the methyltransferase superfamily. Trm-G10 family.
       0.720
MTH_725
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64489 AC:G64489, p()=1.7E-28, pid=31%.
  
  
 0.653
MTH_727
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g149753, p()=6.8E-28, pid=27%; Belongs to the UPF0280 family.
       0.584
nifH1
Nitrogenase NifH subunit; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
  
  
 0.557
nifH2
Nitrogenase NifH subunit; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
  
  
 0.557
cimA
2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
       0.529
MTH_722
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y187_METJA AC:Q57646, p()=0.000000027, pid=21%.
       0.507
MTH_806
Protease IV; Function Code:10.12 - Metabolism of Macromolecules, Degradation of proteins--peptides--and glycopeptides; similar to, sp:LN:Y651_METJA AC:Q58067, p()=2E-35, pid=28%.
  
    0.499
MTH_275
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:YPHE_BACSU AC:P50744, p()=0.62, pid=05%.
 
  
 0.481
MTH_179
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:D64435 AC:D64435, p()=0.17, pid=09%.
  
     0.475
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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