STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MTH_730Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64418 AC:E64418, p()=3E-18, pid=37%. (116 aa)    
Predicted Functional Partners:
MTH_731
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:H64353 AC:H64353, p()=0.9991, pid=03%.
       0.791
MTH_733
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:D152_HAEIN AC:P44935, p()=0.995, pid=15%.
       0.705
tbp
TATA-binding transcription initiation factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
       0.699
MTH_732
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:STAV_STRAV AC:P22629, p()=0.9997, pid=18%.
       0.673
MTH_243
Conserved protein; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family.
       0.670
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
    0.557
MTH_897
Pyrroline-5-carboxylate reductase; Function Code:5.09 - L-Amino Acid Metabolism, Arginine and proline metabolism; similar to, sp:LN:PROC_ECOLI AC:P00373, p()=3.1E-16, pid=21%.
       0.515
rpl37ae
Ribosomal protein L37a; Binds to the 23S rRNA.
   
    0.476
rpl2
Ribosomal protein L8 (E.coli); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
    0.439
rpl23
Ribosomal protein L23a (E.coli); Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family.
   
    0.418
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.