STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_737Coenzyme F420-reducing hydrogenase, delta subunit homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, sp:LN:Y631_METJA AC:Q58048, p()=5.6E-24, pid=34%. (168 aa)    
Predicted Functional Partners:
MTH_738
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64481 AC:C64481, p()=1E-38, pid=38%; To M.jannaschii MJ1452.
       0.906
MTH_739
Conserved protein; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family.
 
     0.863
MTH_736
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:e304651:g1872144 LN:TT11467, p()=1.5E-09, pid=22%.
     
 0.847
frhA
Coenzyme F420-reducing hydrogenase, alpha subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.822
mvhA
Methyl viologen-reducing hydrogenase, alpha subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase.
 
 
 0.801
frhG
Coenzyme F420-reducing hydrogenase, gamma subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the FrhG family.
 
  
 0.695
MTH_398
Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.
 
  
 0.691
MTH_1287
Transcriptional regulator HypF homolog; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, pir:LN:A64389 AC:A64389, p()=1.3E-161, pid=43%; Belongs to the carbamoyltransferase HypF family.
 
   
 0.683
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
   
   0.677
hypA
Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.648
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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