STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_751Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64471 AC:E64471, p()=8.9E-42, pid=36%. (241 aa)    
Predicted Functional Partners:
MTH_752
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:D64368 AC:D64368, p()=1.1E-34, pid=30%.
       0.769
MTH_1813
Serine protease HtrA; Function Code:10.12 - Metabolism of Macromolecules, Degradation of proteins--peptides--and glycopeptides; similar to, gp:GI:g1652463 LN:D90905, p()=1.9E-48, pid=32%.
  
  
 0.619
fen
DNA repair protein Rad2; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathwa [...]
     
 0.531
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.513
MTH_447
Sensory transduction regulatory protein; Function Code:12.12 - Cell Processes, Broad regulatory functions; similar to, gp:GI:g1652473 LN:D90905, p()=5.5E-26, pid=20%.
  
  
 0.490
MTH_233
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64497 AC:E64497, p()=8.6E-44, pid=36%.
     
 0.482
rnz
Conserved protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
     
 0.477
MTH_755
Heavy-metal transporting CPx-type ATPase; Function Code:12.05 - Cell Processes, Transport of cations; similar to, sp:LN:ATKB_ENTFA AC:P05425, p()=3.2E-131, pid=41%.
  
  
 0.474
pstB
Phosphate transport system ATP-binding; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
  
  
 0.459
purC
Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, pir:LN:G64498 AC:G64498, p()=1.6E-65, pid=46%; Belongs to the SAICAR synthetase family.
     
 0.453
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.