Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTH_765GTP-binding protein Rab related protein; Function Code:13.07 - Other, Unclassified; similar to, pir:LN:B64467 AC:B64467, p()=4.8E-27, pid=41%; To M.jannaschii MJ1339. (152 aa)    
Predicted Functional Partners:
MTH_1836
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64389 AC:B64389, p()=6.1E-27, pid=47%.
 
 
 0.971
MTH_503
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64467 AC:C64467, p()=8.2E-23, pid=48%.
 
 
 0.971
MTH_595
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64467 AC:C64467, p()=9.9E-11, pid=23%.
 
 
 0.930
ftsY
Signal recognition particle protein (docking protein); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
  
 0.921
MTH_1828
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1633646 LN:RRU68757, p()=0.6, pid=10%.
  
 
 0.883
MTH_1512
H(2)-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase homolog (II); Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:A64467 AC:A64467, p()=4.5E-102, pid=59%.
  
    0.852
MTH_504
H(2)-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase homolog (III); Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:A64467 AC:A64467, p()=5.1E-101, pid=55%.
  
    0.852
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
       0.779
srp54
Signal recognition particle protein SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
 
 0.778
srp19
Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
   
 
 0.617
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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