STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metECobalamin-independent methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate (By similarity). (308 aa)    
Predicted Functional Partners:
MTH_1636
S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family.
  
 
 0.983
mat
Conserved protein; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
  
  
 0.931
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.917
thyA
Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
     
 0.902
MTH_854
Ferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:FER2_METJA AC:Q57563, p()=6.7E-21, pid=29%.
     
  0.900
MTH_855
Inosine-5'-monophosphate dehydrogenase related protein VIII; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:Y100_METJA AC:Q57564, p()=2.2E-157, pid=64%.
     
 0.900
MTH_1232
Homoserine dehydrogenase; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, sp:LN:DHOM_SYNY3 AC:P52986, p()=8.8E-90, pid=46%.
  
 
 0.883
MTH_417
Homoserine dehydrogenase homolog; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, pir:LN:A64500 AC:A64500, p()=2.1E-79, pid=49%.
  
 
 0.883
MTH_776
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64356 AC:E64356, p()=0.0000013, pid=19%.
       0.883
MTH_777
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:D64356 AC:D64356, p()=6.7E-21, pid=33%.
       0.883
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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