STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (125 aa)    
Predicted Functional Partners:
MTH_1287
Transcriptional regulator HypF homolog; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, pir:LN:A64389 AC:A64389, p()=1.3E-161, pid=43%; Belongs to the carbamoyltransferase HypF family.
 
   
 0.999
MTH_782
Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.
 
 
 0.999
mvhA
Methyl viologen-reducing hydrogenase, alpha subunit; Part of a complex that provides reducing equivalents for heterodisulfide reductase.
  
 
 0.997
frhA
Coenzyme F420-reducing hydrogenase, alpha subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.997
MTH_1176
Nucleotide-binding protein (putative ATPase); Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
 
 0.918
MTH_1072
Hydrogenase expression/formation protein HypD; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:A64424 AC:A64424, p()=1.9E-85, pid=47%.
 
  
 0.912
MTH_1672
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y120_METJA AC:Q57584, p()=8.8E-90, pid=65%.
  
 
 0.887
MTH_1238
Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.
  
 
 0.840
MTH_205
Hydrogenase expression/formation protein HypE; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:D64384 AC:D64384, p()=3.2E-92, pid=45%.
 
  
 0.797
MTH_781
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64383 AC:A64383, p()=2.6E-58, pid=36%.
       0.792
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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