Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
MTH_7923-hydroxy-3-methylglutaryl-CoA-synthase; Function Code:3.04 - Lipid Metabolism, Sterol biosynthesis; similar to, pir:LN:A64493 AC:A64493, p()=8.6E-131, pid=68%; Belongs to the thiolase-like superfamily. UPF0219 family. (349 aa)    
Predicted Functional Partners:
hmgA
3-hydroxy-3-methylglutaryl CoA reductase; Converts HMG-CoA to mevalonate.
 
 0.999
MTH_793
Lipid-transfer protein (sterol or nonspecific); Function Code:3.04 - Lipid Metabolism, Sterol biosynthesis; similar to, pir:LN:D64493 AC:D64493, p()=3.1E-126, pid=63%.
 
 0.999
MTH_1398
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64493 AC:G64493, p()=2.6E-42, pid=54%.
 
 
 0.998
korB
2-oxoglutarate oxidoreductase, beta subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:A64367 AC:A64367, p()=2.1E-88, pid=54%.
    
 0.905
porB
Pyruvate oxidoreductase, beta subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:C64333 AC:C64333, p()=4.6E-109, pid=66%.
    
 0.905
MTH_537
2-oxoacid:ferredoxin oxidoreductase, beta subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:JC4920, p()=5E-48, pid=37%.
    
 0.905
porC
Pyruvate oxidoreductase, gamma subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:F64333 AC:F64333, p()=3.7E-52, pid=42%.
    
 0.903
porA
Pyruvate oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:D64333 AC:D64333, p()=2.3E-114, pid=58%.
    
  0.901
korA
2-oxoglutarate oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:E64334 AC:E64334, p()=3.6E-116, pid=57%.
    
  0.900
MTH_536
2-oxoacid:ferredoxin oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:JC4919, p()=2.7E-67, pid=53%.
    
  0.900
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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