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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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MTH_804Chorismate mutase, subunit A; Function Code:5.11 - Tyrosine metabolism; similar to, pir:LN:G64330 AC:G64330, p()=8.9E-10, pid=32%. (98 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.988
MTH_1640
Chorismate mutase; Function Code:5.14 - L-Amino Acid Metabolism, Phenylalanine--tyrosine and tryptophan biosynthesis; similar to, pir:LN:D64376 AC:D64376, p()=2.9E-82, pid=38%.
 
 
 0.987
rps17e
Ribosomal protein S17; Function Code:10.04 - Metabolism of Macromolecules, Ribosomal proteins; similar to, sp:LN:R17E_METJA AC:P54026, p()=3.3E-12, pid=46%; Belongs to the eukaryotic ribosomal protein eS17 family.
  
    0.984
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
  
  
 0.971
MTH_1220
Chorismate mutase; Function Code:5.14 - L-Amino Acid Metabolism, Phenylalanine--tyrosine and tryptophan biosynthesis; similar to, sp:LN:PHEA_PSEST AC:P27603, p()=2E-51, pid=42%.
  
 
 0.963
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
 
 0.957
trpG
Anthranilate synthase component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
  
 
 0.957
aroA-2
5-enolpyruvylshikimate 3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
  
 0.941
aroB
Conserved protein; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family.
  
  
 0.931
aroK
Conserved protein (homoserine kinase related); Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64479 AC:G64479, p()=1.8E-36, pid=31%.
       0.884
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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