Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
xerAIntegrase-recombinase protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Belongs to the 'phage' integrase family. XerA subfamily. (311 aa)    
Predicted Functional Partners:
dnaG
Conserved protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
 
   
 0.719
sfsA
Sugar fermentation stimulation protein; Function Code:12.12 - Cell Processes, Broad regulatory functions; similar to, sp:LN:SFSA_ECOLI AC:P18273, p()=2.3E-20, pid=25%; Belongs to the SfsA family.
       0.714
MTH_647
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:S61081 AC:S61081:S60817, p()=0.0098, pid=10%.
       0.714
radA
DNA repair protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).
     
 0.689
MTH_892
ATP-dependent protease LA related protein; Function Code:10.12 - Metabolism of Macromolecules, Degradation of proteins--peptides--and glycopeptides; similar to, pir:LN:H64476 AC:H64476, p()=1.2E-42, pid=19%; Belongs to the peptidase S16 family.
 
     0.680
cdc6-1
Cdc6 related protein; Involved in regulation of DNA replication. May play an essential role in origin recognition. Binds to DNA, with a preference for origin-specific double-stranded sequences. Does not bind single- stranded DNA. Inhibits MCM helicase activity but does not affect its oligomeric state. Belongs to the CDC6/cdc18 family.
      
 0.662
MTH_894
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1613873 LN:APU72238, p()=5E-39, pid=24%.
       0.465
MTH_890
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:F64502 AC:F64502, p()=4.5E-15, pid=24%.
       0.442
MTH_889
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:H64339 AC:H64339, p()=1.1E-29, pid=61%.
 
     0.423
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.409
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.