Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MTH_899Transcriptional regulator; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, pir:LN:D64465 AC:D64465, p()=1.6E-17, pid=33%. (122 aa)    
Predicted Functional Partners:
MTH_900
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YQCL_BACSU AC:P45946, p()=7.6E-107, pid=53%.
  
  
 0.940
MTH_894
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1613873 LN:APU72238, p()=5E-39, pid=24%.
  
  
 0.867
MTH_1535
Heavy-metal transporting CPx-type ATPase; Function Code:12.05 - Cell Processes, Transport of cations; similar to, gp:GI:g1353678 LN:PMU42410, p()=1.2E-138, pid=38%.
  
  
 0.819
MTH_898
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64366 AC:C64366, p()=1.3E-26, pid=39%.
     
 0.785
MTH_1355
Arsenate reductase; Function Code:12.11 - Cell Processes, Detoxification; similar to, gp:GI:e266396:g1550684, p()=2E-20, pid=24%.
  
  
 0.726
MTH_897
Pyrroline-5-carboxylate reductase; Function Code:5.09 - L-Amino Acid Metabolism, Arginine and proline metabolism; similar to, sp:LN:PROC_ECOLI AC:P00373, p()=3.1E-16, pid=21%.
  
    0.711
MTH_895
Conserved protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.
     
 0.707
MTH_896
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:CYC3_DESSA AC:P00135, p()=0.29, pid=20%.
       0.701
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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