STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_990Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1652988 LN:D90910, p()=7.4E-22, pid=21%. (338 aa)    
Predicted Functional Partners:
MTH_1109
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64473 AC:B64473, p()=2.2E-45, pid=27%; Belongs to the LarC family.
  
 0.988
MTH_1286
Phosphoribosylaminoimidazole carboxylase related protein; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, pir:LN:F64320 AC:F64320, p()=1.1E-41, pid=41%.
 
  
 0.965
thiI
Conserved protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.857
tbp
TATA-binding transcription initiation factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
      
 0.717
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.707
MTH_907
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1653116 LN:D90911, p()=4.7E-18, pid=26%.
 
    0.647
MTH_772
Conserved protein (contains ferredoxin domain); Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1652823 LN:D90908, p()=2.5E-44, pid=30%.
 
     0.574
cbiM
Cobalamin biosynthesis protein M; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
  
    0.572
MTH_1706
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:YPA1_LEGPN AC:P26880, p()=0.77, pid=12%.
  
    0.572
MTH_1707
Cobalamin biosynthesis protein M; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, pir:LN:H64495 AC:H64495, p()=4.6E-29, pid=31%.
  
    0.572
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.