Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MTH_993Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64366 AC:C64366, p()=4.6E-29, pid=46%. (143 aa)    
Predicted Functional Partners:
MTH_992
Inosine-5'-monophosphate dehydrogenase related protein IX; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, pir:LN:B48868 AC:B48868, p()=1.9E-16, pid=14%.
  
  
 0.804
MTH_994
N-ethylammeline chlorohydrolase related protein; Function Code:13.07 - Other, Unclassified; similar to, pir:LN:C64387 AC:C64387, p()=1.3E-49, pid=35%; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
       0.803
MTH_991
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1877428 LN:SPU40453, p()=0.49, pid=07%.
       0.697
MTH_740
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:IMDH_METKA AC:P50100, p()=6.8E-12, pid=43%.
  
  
 0.569
MTH_995
Lysyl endopeptidase; Function Code:10.12 - Metabolism of Macromolecules, Degradation of proteins--peptides--and glycopeptides; similar to, sp:LN:API_ACHLY AC:P15636, p()=1.5E-11, pid=13%.
  
    0.560
ogt
O6-methylguanidine-DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
  
  
 0.519
MTH_757
Rubredoxin oxidoreductase; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, gp:GI:e258466:g1491677, p()=1.4E-34, pid=51%; Belongs to the desulfoferrodoxin family.
     
 0.493
ftr
Formylmethanofuran:tetrahydromethanopterin formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
      
 0.479
mtd
Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
      
 0.479
carB
Carbamoyl-phosphate synthase, large subunit; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, gp:GI:g1750387 LN:PAU81259, p()=3.6E-219, pid=70%.
     
 0.466
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.