STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ODS41907.1Thermosome subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TCP-1 chaperonin family. (547 aa)    
Predicted Functional Partners:
ODS41908.1
Nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]
  
 0.995
dnaK
Molecular chaperone DnaK; Acts as a chaperone.
  
 
 0.994
ODS41912.1
Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.916
ODS43085.1
Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.831
tbp
Hypothetical protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
  
 
 0.789
pfdA
Prefoldin subunit alpha; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
   
 
 0.789
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.788
ODS42761.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
 
 0.776
ODS42828.1
50S ribosomal protein L4; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.726
infB
Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
  
 
 0.717
Your Current Organism:
Altiarchaeales archaeon
NCBI taxonomy Id: 1878999
Other names: C. Altiarchaeales archaeon IMC4, Candidatus Altiarchaeales archaeon IMC4
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