STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (460 aa)    
Predicted Functional Partners:
ODS41812.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.999
secE
Protein translocase SEC61 complex subunit gamma; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
   
 0.991
rpl18
50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
 
  
 0.782
rpl19e
50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.
 
    0.777
ODS42820.1
50S ribosomal protein L22; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome; Belongs to the universal ribosomal protein uL22 family.
 
  
 0.757
ODS42828.1
50S ribosomal protein L4; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.749
rpl30
50S ribosomal protein L30; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.737
rps5
30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
 
  
 0.728
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
    
 0.724
rps4e
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS4 family.
 
    0.686
Your Current Organism:
Altiarchaeales archaeon
NCBI taxonomy Id: 1878999
Other names: C. Altiarchaeales archaeon IMC4, Candidatus Altiarchaeales archaeon IMC4
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.