STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPC4Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (505 aa)    
Predicted Functional Partners:
FZD1
Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family.
     
 0.907
FZD2
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
     
 0.907
FZD5
Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.
     
 0.907
FZD7
Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family.
     
 0.907
FZD6
Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.
     
 0.907
FZD10
Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family.
     
 0.907
NOTUM
Protein notum.
    
 0.717
Z169_14074
Sonic hedgehog protein.
    
 0.695
SDC2
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
    
 0.676
HS6ST1
Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
     
 0.676
Your Current Organism:
Egretta garzetta
NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.