Z169_14686 protein (Egretta garzetta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

Z169_14686

Uncharacterized protein. (250 aa)

Predicted Functional Partners:

Z169_14684

0.935

Z169_14685

0.929

Z169_14680

0.873

CHDC2

0.807

Z169_14681

0.778

Your Current Organism:

Egretta garzetta

NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHDC2	Z169_14680	A0A091IRL3	A0A091IR79	Calponin homology domain-containing protein 2.	Uncharacterized protein CXorf22.	0.900
CHDC2	Z169_14681	A0A091IRL3	A0A091IN01	Calponin homology domain-containing protein 2.	Uncharacterized protein.	0.900
CHDC2	Z169_14684	A0A091IRL3	A0A091INZ7	Calponin homology domain-containing protein 2.	Uncharacterized protein.	0.848
CHDC2	Z169_14685	A0A091IRL3	A0A091IR83	Calponin homology domain-containing protein 2.	Uncharacterized protein.	0.606
CHDC2	Z169_14686	A0A091IRL3	A0A091IN05	Calponin homology domain-containing protein 2.	Uncharacterized protein.	0.807
Z169_14680	CHDC2	A0A091IR79	A0A091IRL3	Uncharacterized protein CXorf22.	Calponin homology domain-containing protein 2.	0.900
Z169_14680	Z169_14681	A0A091IR79	A0A091IN01	Uncharacterized protein CXorf22.	Uncharacterized protein.	0.925
Z169_14680	Z169_14684	A0A091IR79	A0A091INZ7	Uncharacterized protein CXorf22.	Uncharacterized protein.	0.846
Z169_14680	Z169_14685	A0A091IR79	A0A091IR83	Uncharacterized protein CXorf22.	Uncharacterized protein.	0.709
Z169_14680	Z169_14686	A0A091IR79	A0A091IN05	Uncharacterized protein CXorf22.	Uncharacterized protein.	0.873
Z169_14681	CHDC2	A0A091IN01	A0A091IRL3	Uncharacterized protein.	Calponin homology domain-containing protein 2.	0.900
Z169_14681	Z169_14680	A0A091IN01	A0A091IR79	Uncharacterized protein.	Uncharacterized protein CXorf22.	0.925
Z169_14681	Z169_14684	A0A091IN01	A0A091INZ7	Uncharacterized protein.	Uncharacterized protein.	0.791
Z169_14681	Z169_14685	A0A091IN01	A0A091IR83	Uncharacterized protein.	Uncharacterized protein.	0.745
Z169_14681	Z169_14686	A0A091IN01	A0A091IN05	Uncharacterized protein.	Uncharacterized protein.	0.778
Z169_14684	CHDC2	A0A091INZ7	A0A091IRL3	Uncharacterized protein.	Calponin homology domain-containing protein 2.	0.848
Z169_14684	Z169_14680	A0A091INZ7	A0A091IR79	Uncharacterized protein.	Uncharacterized protein CXorf22.	0.846
Z169_14684	Z169_14681	A0A091INZ7	A0A091IN01	Uncharacterized protein.	Uncharacterized protein.	0.791
Z169_14684	Z169_14685	A0A091INZ7	A0A091IR83	Uncharacterized protein.	Uncharacterized protein.	0.772
Z169_14684	Z169_14686	A0A091INZ7	A0A091IN05	Uncharacterized protein.	Uncharacterized protein.	0.935

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.88

expected number of edges:

12

PPI enrichment p-value:

7.14e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

4 of 30

2.15

2.12

6.84e-05

GO:0006097

Glyoxylate cycle

2 of 2

3.03

1.41

0.0029

GO:0005975

Carbohydrate metabolic process

6 of 447

1.16

0.96

0.0014

GO:0006094

Gluconeogenesis

2 of 12

2.25

0.84

0.0289

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

3 of 13

2.39

1.75

0.00054

GO:0042132

Fructose 1,6-bisphosphate 1-phosphatase activity

2 of 2

3.03

1.34

0.0038

GO:0004108

Citrate (Si)-synthase activity

2 of 2

3.03

1.34

0.0038

GO:0016746

Acyltransferase activity

4 of 188

1.36

0.95

0.0055

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009514

Glyoxysome

2 of 2

3.03

1.33

0.0039

GO:0042597

Periplasmic space

2 of 4

2.73

1.27

0.0049

GO:0005777

Peroxisome

3 of 82

1.59

0.93

0.0118

GO:0005737

Cytoplasm

11 of 4517

0.42

0.32

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9454

Citrate synthase, and Citrate metabolic process

2 of 5

2.63

0.82

0.0323

CL:17099

Mixed, incl. Sequestering of actin monomers, and C4-dicarboxylate transmembrane transporter activity

2 of 5

2.63

0.82

0.0323

CL:11084

Glyoxysome, and Isocitrate lyase

2 of 5

2.63

0.82

0.0323

CL:10111

Glycolytic process, and Insulin effects increased synthesis of Xylulose-5-Phosphate

2 of 18

2.07

0.74

0.0415

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

plj01200

Carbon metabolism

6 of 113

1.75

2.86

5.15e-08

plj00630

Glyoxylate and dicarboxylate metabolism

4 of 36

2.07

2.72

2.29e-06

plj00020

Citrate cycle (TCA cycle)

2 of 28

1.88

1.06

0.0084

plj01210

2-Oxocarboxylic acid metabolism

2 of 32

1.82

1.04

0.0090

plj01110

Biosynthesis of secondary metabolites

5 of 415

1.11

0.96

0.00090

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009514

Glyoxysome

2 of 3

2.85

1.17

0.0078

GOCC:0042597

Periplasmic space

2 of 13

2.22

0.76

0.0406

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00316

Fructose-1-6-bisphosphatase, N-terminal domain

2 of 2

3.03

1.28

0.0050

PF00285

Citrate synthase, C-terminal domain

2 of 3

2.85

1.27

0.0050

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044015

Fructose-1-6-bisphosphatase class 1, C-terminal

2 of 2

3.03

1.03

0.0141

IPR033391

Fructose-1-6-bisphosphatase class I, N-terminal

2 of 2

3.03

1.03

0.0141

IPR020548

Fructose-1,6-bisphosphatase, active site

2 of 2

3.03

1.03

0.0141

IPR019810

Citrate synthase active site

2 of 2

3.03

1.03

0.0141

IPR000146

Fructose-1,6-bisphosphatase class 1

2 of 2

3.03

1.03

0.0141

(more ...)

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