STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERBB4Receptor protein-tyrosine kinase. (1263 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-bound protein 2.
    
 0.999
NRG1
Pro-neuregulin-1, membrane-bound isoform.
    
 0.996
EGF
Pro-epidermal growth factor.
   
 0.991
CBL
E3 ubiquitin-protein ligase CBL.
    
 0.991
HBEGF
Proheparin-binding EGF-like growth factor.
    
 0.983
EREG
Proepiregulin.
    
 0.980
PLCG2
Phosphoinositide phospholipase C.
    
 0.979
PLCG1
Phosphoinositide phospholipase C.
    
 0.979
MET
Hepatocyte growth factor receptor.
   
0.973
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.968
Your Current Organism:
Egretta garzetta
NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.