Z169_10646 protein (Egretta garzetta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

Z169_10646

DENN domain-containing protein 3. (175 aa)

Predicted Functional Partners:

DENND3

0.944

RAB12

0.607

RAB28

0.420

Your Current Organism:

Egretta garzetta

NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DENND3	RAB12	A0A091IVS6	A0A091IPU7	DENN domain-containing protein 3.	Ras-related protein Rab-12.	0.607
DENND3	RAB28	A0A091IVS6	A0A091IQ43	DENN domain-containing protein 3.	Ras-related protein Rab-28.	0.420
DENND3	Z169_10646	A0A091IVS6	A0A091IS54	DENN domain-containing protein 3.	DENN domain-containing protein 3.	0.944
RAB12	DENND3	A0A091IPU7	A0A091IVS6	Ras-related protein Rab-12.	DENN domain-containing protein 3.	0.607
RAB12	Z169_10646	A0A091IPU7	A0A091IS54	Ras-related protein Rab-12.	DENN domain-containing protein 3.	0.607
RAB28	DENND3	A0A091IQ43	A0A091IVS6	Ras-related protein Rab-28.	DENN domain-containing protein 3.	0.420
RAB28	Z169_10646	A0A091IQ43	A0A091IS54	Ras-related protein Rab-28.	DENN domain-containing protein 3.	0.420
Z169_10646	DENND3	A0A091IS54	A0A091IVS6	DENN domain-containing protein 3.	DENN domain-containing protein 3.	0.944
Z169_10646	RAB12	A0A091IS54	A0A091IPU7	DENN domain-containing protein 3.	Ras-related protein Rab-12.	0.607
Z169_10646	RAB28	A0A091IS54	A0A091IQ43	DENN domain-containing protein 3.	Ras-related protein Rab-28.	0.420

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.785

expected number of edges:

11

PPI enrichment p-value:

2.36e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006913

Nucleocytoplasmic transport

11 of 89

1.88

5.41

1.47e-17

GO:0034504

Protein localization to nucleus

7 of 37

2.06

4.49

3.60e-11

GO:0050658

RNA transport

8 of 57

1.93

4.33

8.50e-12

GO:0051028

mRNA transport

7 of 45

1.98

4.14

1.03e-10

GO:0006606

Protein import into nucleus

6 of 30

2.08

3.98

1.47e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017056

Structural constituent of nuclear pore

10 of 17

2.55

9.67

2.47e-21

GO:0005198

Structural molecule activity

11 of 192

1.54

3.37

1.01e-14

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005643

Nuclear pore

11 of 30

2.35

9.31

7.87e-23

GO:0031080

Nuclear pore outer ring

4 of 4

2.78

4.04

2.93e-08

GO:0031965

Nuclear membrane

4 of 27

1.95

2.36

1.01e-05

GO:0044611

Nuclear pore inner ring

2 of 3

2.61

1.51

0.0017

GO:0044613

Nuclear pore central transport channel

2 of 4

2.48

1.43

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2262

Structural constituent of nuclear pore

10 of 16

2.58

9.87

1.34e-21

CL:2264

Structural constituent of nuclear pore

8 of 10

2.69

8.47

1.22e-17

CL:2274

Nuclear pore outer ring, and Nuclear matrix

4 of 5

2.69

3.83

6.25e-08

CL:2265

Nuclear pore inner ring, and NLS-bearing protein import into nucleus

4 of 5

2.69

3.83

6.25e-08

CL:2284

Nuclear RNA export factor complex, and Structural constituent of nuclear pore

2 of 5

2.39

1.23

0.0053

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

11 of 127

1.72

4.55

2.72e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-4085377

SUMOylation of SUMOylation proteins

10 of 25

2.39

8.59

3.66e-20

MAP-5578749

Transcriptional regulation by small RNAs

9 of 22

2.4

7.81

6.70e-18

MAP-159227

Transport of the SLBP independent Mature mRNA

9 of 23

2.38

7.75

6.70e-18

MAP-159234

Transport of Mature mRNAs Derived from Intronless Transcripts

9 of 24

2.36

7.68

6.70e-18

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

9 of 24

2.36

7.68

6.70e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005643

Nuclear pore

10 of 35

2.24

7.58

5.49e-19

GOCC:0005635

Nuclear envelope

11 of 73

1.96

6.16

5.49e-19

GOCC:0044611

Nuclear pore inner ring

2 of 2

2.78

1.57

0.0014

GOCC:0031080

Nuclear pore outer ring

2 of 2

2.78

1.57

0.0014

GOCC:0044613

Nuclear pore central transport channel

2 of 4

2.48

1.39

0.0027

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0906

Nuclear pore complex

3 of 5

2.56

2.37

3.93e-05

KW-0509

mRNA transport

3 of 5

2.56

2.37

3.93e-05

KW-0653

Protein transport

4 of 57

1.63

1.69

0.00011

KW-0175

Coiled coil

6 of 750

0.69

0.44

0.0203

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08801

Nup133 N terminal like

2 of 2

2.78

1.08

0.0109

PF03177

Non-repetitive/WGA-negative nucleoporin C-terminal

2 of 2

2.78

1.08

0.0109

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014908

Nucleoporin, Nup133/Nup155-like, N-terminal

2 of 2

2.78

0.83

0.0322

IPR007187

Nucleoporin, Nup133/Nup155-like, C-terminal

2 of 2

2.78

0.83

0.0322

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