TRAK1 protein (Egretta garzetta) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

TRAK1

Trafficking kinesin-binding protein 1. (961 aa)

Predicted Functional Partners:

RHOT1

0.864

RHOT2

0.818

KIF5B

0.652

KIF5C

0.652

MTX2

0.535

Z169_14454

0.528

HCRTR2

0.524

LYPD6B

0.483

LYPD6

0.483

MFN2

0.471

Your Current Organism:

Egretta garzetta

NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCRTR2	TRAK1	A0A091J828	A0A091J1A1	Orexin receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Trafficking kinesin-binding protein 1.	0.524
KIF5B	KIF5C	A0A091JP35	A0A091K7J1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.901
KIF5B	TRAK1	A0A091JP35	A0A091J1A1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Trafficking kinesin-binding protein 1.	0.652
KIF5C	KIF5B	A0A091K7J1	A0A091JP35	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.901
KIF5C	TRAK1	A0A091K7J1	A0A091J1A1	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Trafficking kinesin-binding protein 1.	0.652
LYPD6	TRAK1	A0A091JIJ7	A0A091J1A1	Ly6/PLAUR domain-containing protein 6.	Trafficking kinesin-binding protein 1.	0.483
LYPD6B	TRAK1	A0A091JGN3	A0A091J1A1	Ly6/PLAUR domain-containing protein 6B.	Trafficking kinesin-binding protein 1.	0.483
MFN2	RHOT1	A0A091JQP0	A0A091IY30	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Mitochondrial Rho GTPase 1.	0.691
MFN2	RHOT2	A0A091JQP0	A0A091IQ37	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Mitochondrial Rho GTPase 2.	0.630
MFN2	TRAK1	A0A091JQP0	A0A091J1A1	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Trafficking kinesin-binding protein 1.	0.471
MFN2	Z169_14454	A0A091JQP0	A0A091JQR4	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Protein kinase domain-containing protein.	0.900
MTX2	TRAK1	A0A091JD17	A0A091J1A1	Metaxin-2.	Trafficking kinesin-binding protein 1.	0.535
RHOT1	MFN2	A0A091IY30	A0A091JQP0	Mitochondrial Rho GTPase 1.	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.691
RHOT1	RHOT2	A0A091IY30	A0A091IQ37	Mitochondrial Rho GTPase 1.	Mitochondrial Rho GTPase 2.	0.901
RHOT1	TRAK1	A0A091IY30	A0A091J1A1	Mitochondrial Rho GTPase 1.	Trafficking kinesin-binding protein 1.	0.864
RHOT1	Z169_14454	A0A091IY30	A0A091JQR4	Mitochondrial Rho GTPase 1.	Protein kinase domain-containing protein.	0.557
RHOT2	MFN2	A0A091IQ37	A0A091JQP0	Mitochondrial Rho GTPase 2.	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.630
RHOT2	RHOT1	A0A091IQ37	A0A091IY30	Mitochondrial Rho GTPase 2.	Mitochondrial Rho GTPase 1.	0.901
RHOT2	TRAK1	A0A091IQ37	A0A091J1A1	Mitochondrial Rho GTPase 2.	Trafficking kinesin-binding protein 1.	0.818
RHOT2	Z169_14454	A0A091IQ37	A0A091JQR4	Mitochondrial Rho GTPase 2.	Protein kinase domain-containing protein.	0.557

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.925

expected number of edges:

12

PPI enrichment p-value:

3.47e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

9 of 10

2.5

8.01

1.26e-17

GO:0046417

Chorismate metabolic process

8 of 8

2.54

7.39

7.49e-16

GO:0009423

Chorismate biosynthetic process

7 of 7

2.54

6.39

1.43e-13

GO:0016053

Organic acid biosynthetic process

10 of 158

1.34

2.28

3.71e-11

GO:0008652

Cellular amino acid biosynthetic process

8 of 112

1.4

2.16

1.24e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004764

Shikimate 3-dehydrogenase (NADP+) activity

2 of 2

2.54

0.83

0.0304

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

2 of 4

2.24

0.78

0.0371

GO:0016835

Carbon-oxygen lyase activity

3 of 32

1.51

0.7

0.0371

GO:0016829

Lyase activity

4 of 95

1.17

0.6

0.0371

GO:0003824

Catalytic activity

11 of 1844

0.32

0.24

0.0451

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25072253

(2014) Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis.

3 of 3

2.54

1.55

0.0014

PMID:24586713

(2014) Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.

3 of 3

2.54

1.55

0.0014

PMID:35163582

(2022) Comparison of Automated Ribotyping, spa Typing, and MLST in 108 Clinical Isolates of Staphylococcus aureus from Orthopedic Infections.

3 of 4

2.42

1.54

0.0014

PMID:32391366

(2020) Prevalence, Characterization, and Drug Resistance of Staphylococcus Aureus in Feces From Pediatric Patients in Guangzhou, China.

3 of 5

2.32

1.52

0.0014

PMID:36873553

(2023) The effect of different C. difficile MLST strains on viability and activity of macrophages.

3 of 6

2.24

1.51

0.0014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1319

Aromatic amino acid family biosynthetic process, and CorA, cytoplasmic domain

9 of 12

2.42

7.64

2.90e-17

CL:1322

Chorismate metabolic process

6 of 6

2.54

5.46

1.70e-11

CL:1291

Mixed, incl. Histidine biosynthetic process, and Aromatic amino acid family biosynthetic process

10 of 43

1.91

5.27

5.00e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pdc00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 17

2.31

8.23

4.91e-20

pdc01230

Biosynthesis of amino acids

9 of 116

1.43

2.53

8.08e-11

pdc01110

Biosynthesis of secondary metabolites

10 of 235

1.17

1.71

3.28e-10

pdc01100

Metabolic pathways

11 of 605

0.8

0.85

4.23e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 7

2.54

6.47

9.59e-14

KW-0521

NADP

3 of 23

1.66

1.19

0.0030

KW-0456

Lyase

4 of 92

1.18

0.85

0.0055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08501

Shikimate dehydrogenase substrate binding domain

2 of 2

2.54

0.86

0.0274

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