node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRCA2 | FAN1 | A0A091INQ8 | A0A091JHT2 | Breast cancer type 2 susceptibility protein. | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | 0.412 |
BRCA2 | FANCB | A0A091INQ8 | A0A091JXC3 | Breast cancer type 2 susceptibility protein. | Fanconi anemia group B protein. | 0.535 |
BRCA2 | FANCC | A0A091INQ8 | A0A091JCC7 | Breast cancer type 2 susceptibility protein. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.620 |
BRCA2 | FANCD2 | A0A091INQ8 | A0A091J6U1 | Breast cancer type 2 susceptibility protein. | Fanconi anemia group D2 protein. | 0.986 |
BRCA2 | FANCI | A0A091INQ8 | A0A091J1C7 | Breast cancer type 2 susceptibility protein. | Fanconi anemia group I protein. | 0.730 |
BRCA2 | FANCL | A0A091INQ8 | A0A091JCC4 | Breast cancer type 2 susceptibility protein. | E3 ubiquitin-protein ligase FANCL. | 0.693 |
BRCA2 | UBE2T | A0A091INQ8 | A0A091JK40 | Breast cancer type 2 susceptibility protein. | Ubiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. | 0.458 |
BRCA2 | USP1 | A0A091INQ8 | A0A091J262 | Breast cancer type 2 susceptibility protein. | Ubiquitin carboxyl-terminal hydrolase. | 0.459 |
BRCA2 | Z169_08646 | A0A091INQ8 | A0A091J2S6 | Breast cancer type 2 susceptibility protein. | Fanconi anemia-associated protein of 24 kDa. | 0.545 |
FAN1 | BRCA2 | A0A091JHT2 | A0A091INQ8 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Breast cancer type 2 susceptibility protein. | 0.412 |
FAN1 | FANCB | A0A091JHT2 | A0A091JXC3 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Fanconi anemia group B protein. | 0.569 |
FAN1 | FANCC | A0A091JHT2 | A0A091JCC7 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.469 |
FAN1 | FANCD2 | A0A091JHT2 | A0A091J6U1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Fanconi anemia group D2 protein. | 0.991 |
FAN1 | FANCE | A0A091JHT2 | A0A091J3B5 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Fanconi anemia group E protein. | 0.449 |
FAN1 | FANCI | A0A091JHT2 | A0A091J1C7 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Fanconi anemia group I protein. | 0.847 |
FAN1 | FANCL | A0A091JHT2 | A0A091JCC4 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | E3 ubiquitin-protein ligase FANCL. | 0.726 |
FAN1 | UBE2T | A0A091JHT2 | A0A091JK40 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Ubiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. | 0.410 |
FAN1 | USP1 | A0A091JHT2 | A0A091J262 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Ubiquitin carboxyl-terminal hydrolase. | 0.430 |
FAN1 | Z169_08646 | A0A091JHT2 | A0A091J2S6 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Fanconi anemia-associated protein of 24 kDa. | 0.784 |
FANCB | BRCA2 | A0A091JXC3 | A0A091INQ8 | Fanconi anemia group B protein. | Breast cancer type 2 susceptibility protein. | 0.535 |