STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (132 aa)    
Predicted Functional Partners:
NPC1
Niemann-Pick C1 protein.
   
 0.762
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.760
CHAF1B
Chromatin assembly factor 1 subunit B.
    
 
 0.727
ASF1A
Histone chaperone ASF1.
   
 
 0.580
ORC3
Origin recognition complex subunit 3.
    
   0.545
ORC5
Origin recognition complex subunit 5.
    
   0.545
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.458
AMFR
E3 ubiquitin-protein ligase AMFR.
    
 
 0.453
Z169_05494
Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.
    
 
 0.431
GRB14
Growth factor receptor-bound protein 14.
      
 0.407
Your Current Organism:
Egretta garzetta
NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.