STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TDP2Tyrosyl-DNA phosphodiesterase 2. (276 aa)    
Predicted Functional Partners:
TDP1
Tyrosyl-DNA phosphodiesterase 1.
   
  
 0.700
Z169_08292
Small ubiquitin-related modifier.
   
 
 0.663
RPS27A
Ubiquitin-40S ribosomal protein S27a.
    
 
 0.635
ORC2
Origin recognition complex subunit 2.
      
 0.619
XRCC6
X-ray repair cross-complementing protein 5.
     
 0.607
SUMO1
Small ubiquitin-related modifier.
   
 
 0.599
Z169_01372
Uncharacterized protein C6orf62.
 
    
 0.573
UBB
Polyubiquitin-C.
    
 
 0.553
ACOT13
Acyl-coenzyme A thioesterase 13.
      
 0.536
TOP1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
      
 0.507
Your Current Organism:
Egretta garzetta
NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.