HYKK protein (Egretta garzetta) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

HYKK

Hydroxylysine kinase. (377 aa)

Predicted Functional Partners:

PHYKPL

0.993

AGXT2

0.923

PSMA4

0.787

ALDH18A1

0.763

Z169_06577

0.594

HPD

0.572

KYNU

0.565

AASDH

0.565

ADI1

0.556

GOT2

0.548

Your Current Organism:

Egretta garzetta

NCBI taxonomy Id: 188379
Other names: E. garzetta, little egret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASDH	AGXT2	A0A091JGJ3	A0A091KH42	Acyl-CoA synthetase family member 4.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.878
AASDH	GOT2	A0A091JGJ3	A0A091JIA6	Acyl-CoA synthetase family member 4.	Aspartate aminotransferase.	0.517
AASDH	HYKK	A0A091JGJ3	A0A091JJL4	Acyl-CoA synthetase family member 4.	Hydroxylysine kinase.	0.565
AASDH	KYNU	A0A091JGJ3	A0A091JDG2	Acyl-CoA synthetase family member 4.	Kynureninase.	0.446
AASDH	PHYKPL	A0A091JGJ3	A0A091K2K0	Acyl-CoA synthetase family member 4.	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.878
AASDH	Z169_06577	A0A091JGJ3	A0A091JGF0	Acyl-CoA synthetase family member 4.	Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family.	0.543
ADI1	GOT2	A0A091IXL1	A0A091JIA6	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family.	Aspartate aminotransferase.	0.510
ADI1	HYKK	A0A091IXL1	A0A091JJL4	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family.	Hydroxylysine kinase.	0.556
AGXT2	AASDH	A0A091KH42	A0A091JGJ3	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Acyl-CoA synthetase family member 4.	0.878
AGXT2	ALDH18A1	A0A091KH42	A0A091JD75	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Delta-1-pyrroline-5-carboxylate synthase.	0.707
AGXT2	HYKK	A0A091KH42	A0A091JJL4	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Hydroxylysine kinase.	0.923
AGXT2	KYNU	A0A091KH42	A0A091JDG2	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Kynureninase.	0.410
ALDH18A1	AGXT2	A0A091JD75	A0A091KH42	Delta-1-pyrroline-5-carboxylate synthase.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.707
ALDH18A1	GOT2	A0A091JD75	A0A091JIA6	Delta-1-pyrroline-5-carboxylate synthase.	Aspartate aminotransferase.	0.698
ALDH18A1	HPD	A0A091JD75	A0A091IYQ1	Delta-1-pyrroline-5-carboxylate synthase.	4-hydroxyphenylpyruvate dioxygenase.	0.698
ALDH18A1	HYKK	A0A091JD75	A0A091JJL4	Delta-1-pyrroline-5-carboxylate synthase.	Hydroxylysine kinase.	0.763
ALDH18A1	PHYKPL	A0A091JD75	A0A091K2K0	Delta-1-pyrroline-5-carboxylate synthase.	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.720
ALDH18A1	Z169_06577	A0A091JD75	A0A091JGF0	Delta-1-pyrroline-5-carboxylate synthase.	Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family.	0.733
GOT2	AASDH	A0A091JIA6	A0A091JGJ3	Aspartate aminotransferase.	Acyl-CoA synthetase family member 4.	0.517
GOT2	ADI1	A0A091JIA6	A0A091IXL1	Aspartate aminotransferase.	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family.	0.510

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.695

expected number of edges:

15

PPI enrichment p-value:

0.234

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051028

mRNA transport

10 of 79

2.7

10.92

3.66e-23

GO:0006406

mRNA export from nucleus

9 of 56

2.8

10.61

8.32e-22

GO:0006397

mRNA processing

6 of 414

1.76

2.83

6.86e-08

GO:0010467

Gene expression

11 of 1776

1.39

2.62

1.99e-13

GO:0016973

poly(A)+ mRNA export from nucleus

2 of 22

2.56

1.44

0.0023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1120

1.59

3.6

6.56e-15

GO:0003729

mRNA binding

5 of 205

1.98

2.92

4.19e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000445

THO complex part of transcription export complex

5 of 8

3.39

6.81

4.04e-13

GO:0016607

Nuclear speck

5 of 143

2.14

3.57

2.85e-08

GO:0140513

Nuclear protein-containing complex

8 of 1136

1.44

2.32

7.61e-09

GO:0005681

Spliceosomal complex

3 of 278

1.63

1.22

0.0023

GO:0005634

Nucleus

11 of 5174

0.92

1.08

1.22e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8411

mRNA export from nucleus, and THO complex subunit 2

9 of 30

3.07

12.05

1.08e-23

CL:8409

mRNA transport, and Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

10 of 66

2.78

11.61

3.37e-24

CL:8419

THO complex, and poly(A)+ mRNA export from nucleus

8 of 19

3.22

11.26

9.85e-22

CL:8408

Mixed, incl. RNA Polymerase II Transcription Termination, and Regulation of RNA splicing

11 of 116

2.57

11.24

3.62e-25

CL:8423

THO complex

5 of 10

3.3

6.67

6.50e-13

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu03040

Spliceosome

6 of 109

2.34

5.17

1.68e-11

aqu03013

RNA transport

6 of 125

2.28

5.05

1.86e-11

aqu03015

mRNA surveillance pathway

2 of 66

2.08

1.19

0.0054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73856

RNA Polymerase II Transcription Termination

11 of 97

2.65

12.14

1.31e-26

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

11 of 100

2.64

12.08

1.31e-26

MAP-72202

Transport of Mature Transcript to Cytoplasm

11 of 111

2.59

11.82

1.77e-26

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 476

1.96

6.32

7.74e-20

MAP-8953854

Metabolism of RNA

11 of 1040

1.62

3.9

3.11e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000347

THO complex

5 of 10

3.3

6.52

1.20e-12

GOCC:0000346

Transcription export complex

5 of 11

3.25

6.51

1.20e-12

GOCC:0000445

THO complex part of transcription export complex

3 of 6

3.3

3.71

1.88e-07

GOCC:0016607

Nuclear speck

3 of 29

2.61

2.75

7.38e-06

GOCC:0005634

Nucleus

11 of 2291

1.28

2.15

3.35e-12

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

4 of 246

1.81

1.88

8.76e-05

KW-0508

mRNA splicing

2 of 22

2.56

1.46

0.0021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16134

THO complex subunit 2 N-terminus

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR032302

THO complex subunit 2, N-terminal domain

2 of 2

3.6

1.89

0.00040

IPR000504

RNA recognition motif domain

4 of 158

2.0

1.78

0.00028

IPR035979

RNA-binding domain superfamily

4 of 177

1.95

1.75

0.00028

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

4 of 186

1.93

1.74

0.00028

IPR040007

THO complex subunit 2

2 of 6

3.12

1.57

0.0015

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

4 of 151

2.02

2.23

2.68e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

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